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Super enhancers have been shown to regulate the expression of oncogenes like Myc. These super enhancers...

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Biology

Super enhancers have been shown to regulate the expression ofoncogenes like Myc. These super enhancers can be targeted by smallmolecule inhibitors to histone readers like BRD4. Inhibitinghistone readers like BRD4 has been leveraged as a therapeuticstrategy to repress oncogene expression (i.e. Myc) in specifictumor types. Can you further explain the rationale behind thisapproach by addressing the following questions? A.) Does BRD4occupy super enhancers to a different extent than regularenhancers? If so, why does BRD4 bind to super enhancersdifferently? B.) Would BRD4 inhibition affect normal enhancers inthe patient’s body to the same extent as the active super enhancersin the patient’s tumor? If yes or no why? C.) Would BRD4 inhibitionin tumors of different origin (lymphoma vs neuroblastoma) affectthe expression of the same oncogenes? If yes or no why?

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ANSWER A Enhancer is basically a sequence which is regulatory in function BRD4 also called as bromodomain acts as a transcriptional activator which tends to binds to super enhancers more effectively than that of the enhancers BRD4 acts as a histone reader which tends to identify the Acetylated lysine residues in histone as a part of histone modification BRD4 binding to chromatin having enhancer region would not show much binding strength as    See Answer
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