So for a paper I need to determine strengths and weaknesses of research methods in different...

70.2K

Verified Solution

Question

Medical Sciences

So for a paper I need to determine strengths and weaknesses ofresearch methods in different articles, but I don't exactly knowwhat I should be listing as strengths and weaknesses when assessingthe methods, results, and conclusions. I need help breaking downthis methods paragraph to understand what to be looking for.

\"In this double-blind, placebo-controlled trial conducted at 30clinical centers, we randomly assigned patients with theLennox–Gastaut syndrome (age range, 2 to 55 years) who had had twoor more drop seizures per week during a 28-day baseline period toreceive cannabidiol oral solution at a dose of either 20 mg perkilogram of body weight (20-mg cannabidiol group) or 10 mg perkilogram (10-mg cannabidiol group) or matching placebo,administered in two equally divided doses daily for 14 weeks. Theprimary outcome was the percentage change from baseline in thefrequency of drop seizures (average per 28 days) during thetreatment period.

A total of 225 patients were enrolled; 76 patients were assignedto the 20-mg cannabidiol group, 73 to the 10-mg cannabidiol group,and 76 to the placebo group. During the 28-day baseline period, themedian number of drop seizures was 85 in all trial groups combined.The median percent reduction from baseline in drop-seizurefrequency during the treatment period was 41.9% in the 20-mgcannabidiol group, 37.2% in the 10-mg cannabidiol group, and 17.2%in the placebo group (P=0.005 for the 20-mg cannabidiol group vs.placebo group, and P=0.002 for the 10-mg cannabidiol group vs.placebo group). The most common adverse events among the patientsin the cannabidiol groups were somnolence, decreased appetite, anddiarrhea; these events occurred more frequently in the higher-dosegroup. Six patients in the 20-mg cannabidiol group and 1 patient inthe 10-mg cannabidiol group discontinued the trial medicationbecause of adverse events and were withdrawn from the trial.Fourteen patients who received cannabidiol (9%) had elevated liveraminotransferase concentrations.

Among children and adults with the Lennox–Gastaut syndrome, theaddition of cannabidiol at a dose of 10 mg or 20 mg per kilogramper day to a conventional antiepileptic regimen resulted in greaterreductions in the frequency of drop seizures than placebo. Adverseevents with cannabidiol included elevated liver aminotransferaseconcentrations.\"

Sorry for how long winded this is but any help is greatlyappreciated. Thanks.

Answer & Explanation Solved by verified expert
4.3 Ratings (787 Votes)
A trial conducted in 30 clinical centres for Lennox Gastaut syndrome patients they gave cannabidial for these patients includes children and adults 2 to55 yrs age there are 3 groups total 225 patients 76 patients are in 20mg cannabidial group 20mg per kilogram of body weight 73 patients are in 10mg cannabidial group10mg per kilogram of    See Answer
Get Answers to Unlimited Questions

Join us to gain access to millions of questions and expert answers. Enjoy exclusive benefits tailored just for you!

Membership Benefits:
  • Unlimited Question Access with detailed Answers
  • Zin AI - 3 Million Words
  • 10 Dall-E 3 Images
  • 20 Plot Generations
  • Conversation with Dialogue Memory
  • No Ads, Ever!
  • Access to Our Best AI Platform: Flex AI - Your personal assistant for all your inquiries!
Become a Member

Other questions asked by students