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Side effects of Avandia Rosiglitazone is the active ingredient in the controversial type 2 diabetes...

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Side effects of Avandia Rosiglitazone is the active ingredient in the controversial type 2 diabetes medicine Avandia and has been linked to an increased risk of serious cardiovascular problems such as stroke heart failure and death A common alternative treatment is Pioglitazone the active ingredient in a diabetes medicine called Actos In a nationwide retrospective observational study of 227 571 Medicare beneficiaries aged 65 years or older it was found that 2 593 of the 67 593 patients using Rosiglitazone and 5 386 of the 159 978 using Pioglitazone had serious cardiovascular problems These data are summarized in the contingency table below treatment Yes Pioglitazone 5 386 Rosiglitazone 2 593 7 979 Total No 154 592 65 000 219 592 a What proportion of all patients had cardiovascular problems Total 159 978 67 593 227 571 b If the type of treatment and having cardiovascular problems were independent about how many patients in the Rosiglitazone group would we expect to have had cardiovascular problems

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