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Sickle cell anemia is inherited as an autosomal, recessivedisorder. Individuals who inherit the mutated gene from bothparents will show symptoms of sickle cell, including a stiffeningof the red blood cells when the individual is under conditions withlow oxygen levels in the air (e.g. on top of a mountain). This canlead to low red blood cell count (anemia), shortness of breath,fatigue, jaundice, and joint pain. Most critically, the stiffenedred blood cells can clog small blood vessels, blocking blood flowto critical organs (e.g. brain, lungs, liver, etc.) that can leadto death. Curiously, heterozygous carriers have a certain amount ofresistance to malaria. The malaria parasite must invade red bloodcells in order to develop and apparently the cell surface isaltered in heterozygous individuals, thereby limiting the abilityof the malaria parasite to enter the red blood cells. Recall thatthe rules for autosomal recessive diseases are that only thehomozygous recessive individuals experience the symptoms of sicklecell anemia.

C.   Determine the results of a mating between two parents that are bothheterozygous for sickle cell anemia.

1. Provide the Punnett square and the potential offspringphenotypes and genotypes.
2. What percentage of children from this mating will developsickle cell anemia?
3. What percentage of children from this mating will carry atleast one sickle cell allele?