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Scenario 9: A health economist has undertaken the one-way deterministic sensitivity analysis of a new stroke management program compared with the status quo. The base-case ICER is $1500 per QALY gain. Please refer to the attached table for sensitivity ICERS, when QALY and cost parameters were manually changed. Answer questions 9.1 through 9.3. Question 9.1: Calculate % change in the base-case ICERs for utilities of stroke patients when the QALY parameter was assumed lower and higher values, respectively. Refer to the Tornado table attached. (% change in the base-ICER when assumed lower value: ___;% change in the base-case ICER when assumed higher value: Question 9.2: Calculate % change in the base-case ICERs for hospitalization when cost parameter was assumed lower and higher values, respectively. Refer to the Tornado table attached. (% change in the base-ICER when assumed lower value: % change in the base-case ICER when assumed higher value: Question 9.3: Calculate % change in the base-case ICERs for intervention when cost parameter was assumed lower and higher values, respectively. Refer to the Tornado table attached. (% change in the base-ICER when assumed lower value: % change in the base-case ICER when assumed higher value:_ The ICER with base-case One-way deterministic results (Costs and QALYS) Parameters 1. Utilities (QALYS) of severe stroke patients 2. hospitalization costs 3. Intervention cost The ICER with a lower bound estimate The ICER with a higher bound estimate $900 $1,800 $1,100 $2,400 $1,400 $1,600 $1,500 Tornado Table Parameters % change in the base-case ICER with high value for parameters % change in the base- case ICER with low value for parameters ? ? ? Utilities of Stroke patients, -10%, +10% Hospitalization costs, -25%, +25% Intervention costs, -25%, +25% ? ? ? Scenario 9: A health economist has undertaken the one-way deterministic sensitivity analysis of a new stroke management program compared with the status quo. The base-case ICER is $1500 per QALY gain. Please refer to the attached table for sensitivity ICERS, when QALY and cost parameters were manually changed. Answer questions 9.1 through 9.3. Question 9.1: Calculate % change in the base-case ICERs for utilities of stroke patients when the QALY parameter was assumed lower and higher values, respectively. Refer to the Tornado table attached. (% change in the base-ICER when assumed lower value: ___;% change in the base-case ICER when assumed higher value: Question 9.2: Calculate % change in the base-case ICERs for hospitalization when cost parameter was assumed lower and higher values, respectively. Refer to the Tornado table attached. (% change in the base-ICER when assumed lower value: % change in the base-case ICER when assumed higher value: Question 9.3: Calculate % change in the base-case ICERs for intervention when cost parameter was assumed lower and higher values, respectively. Refer to the Tornado table attached. (% change in the base-ICER when assumed lower value: % change in the base-case ICER when assumed higher value:_ The ICER with base-case One-way deterministic results (Costs and QALYS) Parameters 1. Utilities (QALYS) of severe stroke patients 2. hospitalization costs 3. Intervention cost The ICER with a lower bound estimate The ICER with a higher bound estimate $900 $1,800 $1,100 $2,400 $1,400 $1,600 $1,500 Tornado Table Parameters % change in the base-case ICER with high value for parameters % change in the base- case ICER with low value for parameters ? ? ? Utilities of Stroke patients, -10%, +10% Hospitalization costs, -25%, +25% Intervention costs, -25%, +25%

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