Scenario 2: You are informed that an endocrine organ in the body expresses four membrane receptors...

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Medical Sciences

Scenario 2: You are informed that an endocrine organ in the bodyexpresses four membrane receptors a) receptor-i which is Gs coupledb) receptor-ii which is Gi coupled c) receptor-iii which is Gqcoupled d) receptor-iv is a receptor guanylyl cyclase You arefurther informed that an increase in Ca2+ concentration or anincrease in the active PKA levels inside the organ both will resultin release of hormone from this endocrine organ. On the other hand,PKG inhibits the release of hormone from this organ. What would bethe expected outcome (increased blood concentration of hormone ordecreased blood concentration of hormone) with the following drugs:Q4. Receptor 1 agonist? 1 point
Q5. Receptor 1 antagonist? 1 point
Q6. Receptor 2 agonist? 1 point
Q7. Receptor 2 antagonist? 1 point
Q8. Receptor 3 agonist? 1 point
Q9. Receptor 3 antagonist? 1 point
Q10. Receptor 4 agonist? 1 point
Q11. Receptor 4 antagonist? 1 point

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3.6 Ratings (581 Votes)

We can write the data provided in points for easier interpretation 1 The enzyme levels rise with rise in PKA and Ca ionsIt decreases with rise in PKG 2 Agonist produce action at the receptor and Antagonist inhibit it 3 Function of receptors given and See Answer

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