Scenario 2.
Normally viruses infect a host cell, replicate themselves inside itand burst the host cell so that they can go on infecting othercells. In this viral infection, the virus has stopped the normalapoptotic pathway to allow themselves to stay within the cellindefinitely – a phenomenon known as latency. Further studies onthis virus has shown that the virus encodes inhibitors of caspase 8activation.

Scenario 2 describes the development and maintenance of a latentviral infection, allowing the virus to persist in the host cell. Ifwe assume that the infection has already developed latency in thepatient (i.e. the person is already infected and the virus ispersisting in the cell), which of the following methods would bethe MOST APPROPRIATE method to eradicate the virus from the hostcell and stop the latent infection?

Select one:
a. Develop a vaccine against the virus, which enhances apoptosisvia the intrinsic pathway
b. Block viruses from inserting their nucleic acids into a hostcell
c. Upregulate the expression of DISC assembly proteins
d. Promote the release of cytochrome C in all cells

Scenario 3. Parkinson’s disease is a chronic neurodegenerativedisorder characterised by uncontrollable tremors and musclerigidity. Studies have linked Parkinsons disease with mutations inseveral different genes, one of which is PINK1. Studies have shownthat in PINK1 deficient human and mouse neurons there was anincrease in cytochrome C release from the mitochondrion.

Scenario 3 describes the development of Parkinson's disease inneurons due to the accumulation of mutations in PINK1 (aswell as other genes). Based on your knowledge of cell death, thefunction of PINK1 is most similar to that of...?

Select one:

a. Puma

b. Bcl-2

c. IAPs

d. p53

e. Bak