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Scenario 1.   A recent research publication connected migraine headache frequency with a single nucleotide polymorphism.  The affected gene encodes...

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Biology

Scenario 1.  

A recent research publication connected migraine headachefrequency with a single nucleotide polymorphism.  Theaffected gene encodes the TRPM8 channel protein that transportsions across a membrane.  Interestingly, this geneticvariation may have become common in northern European populationsbecause it also grants them a higher tolerance to coldtemperatures

1.  Sequencing of the TRPM8 gene and thesurrounding region of the chromosome has been completed.

  1. Describe how you know where transcription of this gene wouldstart.
  2. Describe how you know where translation of this gene wouldstart.

2.  Using the TRPM8 gene/protein as anexample, indicate where you would find this type of bond, what theyare made from, and describe how they are formed.

a)  phosphodiester bonds

b)  peptide bonds

3.  A new TRPM8 mutation has been identified in afamily in Indiana.  This protein has a missense mutationin the sequence that results in a mutation labelled T118S.

a)  What does this mutation notation indicate?

b)  Using the genetic code, dictate the RNA sequencefor this region.

c)  What is the DNA sequence of the template strandfor this region?

Answer & Explanation Solved by verified expert
3.8 Ratings (577 Votes)
1 a Ans Transcription and Translation TRPM8 is being potentially one such gene the only known receptor for the sensation of moderate cold temperature TRPM8 single nucleotide polymorphisms SNPs are being associated with both migraine with and without aura and show little selectivity for any of the migraine characteristics The SNPs rs7577262 rs10166942 are 7 kb and 950 bp upstream of the transcription start site for TRPM8 mRNA respectively Carriers of the rarer allele of rs10166942 C C or C T have a lower risk of migraine compared with those carrying two common alleles T T Another SNP rs17862920 is in the first intron of    See Answer
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