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RNase is an enzyme that cleaves the P 05 bond in RNA It has two...

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RNase is an enzyme that cleaves the P 05 bond in RNA It has two His residues in the active site Suggest a plausible explanation why the enzyme activity changes when pH is increased or decreased from pH 6 0 as shown in the graph Activity 120 100 80 60 40 20 0 10 pH Data provided by Dr Sunita Chowrira University of British Columbia Choose all of the true statements Both His residues are deprotonated at pH higher than than 6 5 The substrate is affected by the change in pH and is inactive postively charged when pH is above 6 0 The RNase reaction is an example of metal ion catalysis with a positively charged metal There are two His residues and both are deprotonated below pH 4 2 RNAse is an acid base catalyst

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