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Research in cell biology and metabolism has progressed due to the discovery of molecules that artificially...

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Biology

Research in cell biology and metabolism has progressed due tothe discovery of molecules that artificially stimulate or inhibitglucagon/epinephrine and insulin signaling pathways. Let’s say youare working in a lab cataloging the effects of a library of smallmolecules on these pathways and have a “hit” on molecule 1stAVNGR.Preliminary data on molecule 1stAVNGRindicates that the cardiacisoform of PFK2/FBPase2 is doubly phosphorylated when this moleculeis present at micromolar concentrations in cell cultures.

A. In consideration of the data presented in this problem whatwould be the expected effect of molecule 1stAVNGRon glycolytic fluxin a culture of cardiac myocytes? Explain your reasoning?

B.Finally, if molecule 1stAVNGRwere infused into a culture ofhepatocytes what would be the expected effect on glycolytic flux inthese cells? Explain your reasoning.

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