Relate the following complexes to cell-cell interactions
(adherens junctions, desmosomes, tight junctions, & gap
junctions) or cell-ECM...
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Biology
Relate the following complexes to cell-cell interactions(adherens junctions, desmosomes, tight junctions, & gapjunctions) or cell-ECM interactions
oCadherins
oIntegrins
oClaudins
oActin
oCatenins
oIntermediate filaments (keratin)
oConnexins
oElastin/collagen
oFibronectin/laminin
oProteoglycans
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Cadherins Cadherins are the transmembrane proteins that help in cell to cell adhesion in animals It plays a vital role in tissue morphogenesis and homeostasis During morphogenesis tissue can change in size and shape and form a distinct cell layers Cadherins functions in tissue morphogenesis by controlling cellcell adhesion and cell signalling Cadherins and cell adhesion When cell contact cadherins forms a transbonds across at the site of contact between the two cells Once the transbonds are formed cadherins regulate the cell cell contact in 3 ways Reduces local interfacial tension directly through cell adhesion tension Reduces local interfacial tension indirectly by signalling to actomyosin cytoskeleton Establishes the mechanical coupling of contacting cells Integrins Integrins are the transmembrane cellmatrix adhesion receptors Integrins serve as cellcell adhesion molecules which help cells to bind to
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