Read the scenario then answer the question:

When Ahmad and Amina decided to get married, they were worriedthat their coming children might suffer from Sickle cell disease,since Amina’s mother had the disease. But the doctor made thingsclear ….

DOC: “Unfortunately Mr. Ahmad after tracking your family’sgenetics you might be carrying the recessive allele for the diseaseso there is a 25% chance your children might be anemic. “

PARENTS: “ So does that mean that 25% might not even carry thedisease allele?

And 50% will carry the allele but won’t have the disease? Did wemention to you that we are cousins? “

Doctor: “ Well now it makes much more sense! Children offirst-cousin marriages have an increased risk of autosomalrecessive genetic disorders, just like sickle cell disease, whichcomes from a recessive allele. Two cousins might both carry therecessive allele and transmit it both to their child which willbecome ill unfortunately, just like sickle cell disease.

PARENTS: “ Unfortunately, my son Seif was born with sickle cellanemia and is getting medication to carry on his life normally. Mydaughter Shamsa doesn’t suffer from the disease, but she mightcarry the recessive gene and might have anemic children in thefuture. “

-----

INFORMATION:

•You should know that S is the dominant allele for normal bloodcells, and s is the recessive allele for sickle cell anemia

•Phenotypes are normal for normal trait and anemic for recessivetrait

•In the pedigree we see the cross of the heterozygousparents

question:

Write a neat and full text about your analysis of thefamily’s inheritance, explain how the disease inheritance isaffected by cousins marrying each other, and give solutions toreduce the probability of getting the disease. (350words)

Enforce your work by doing further research, make sureto insert pictures or any document that you believe can show yourwork and express your ideas. Do your research on mendeliangenetics, inherited diseases, autosomal and gonosomal, patterns ofinheritance etc…