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Question 1. Cystic Fibrosis (CF) is an example of a protein mis-folding disorder since most of...

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Biology

Question 1. Cystic Fibrosis (CF) is an exampleof a protein mis-folding disorder since most of the mutationsassociated with CF lead to the improper folding and processing ofthe plasma membrane-localized Cystic Fibrosis TransmembraneConductance Regulator ion channel (CFTR).

The CFTR protein initially entersthe endomembrane system through the process of co-translationaltranslocation into the endoplasmic reticulum (ER) and is insertedas a Type IV membrane protein. N-linked glycosylation of the CFTRprotein then takes place in the ER and continues in theGolgi.

Name the four types ofsequence signals in the CFTR protein required for its propertargeting and processing up to this point (the Golgi) and give anexplanation for each.

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3.6 Ratings (371 Votes)
After translation process in ribosomes the polypeptide chain generated undergoes several posttranslational modifications and changes and are translocated to other area of the cell or secreted out of the cell by the process of protein trafficking The proteins are recognized by a short signal sequence 612 amino acid sequence present at the Nterminus and are targeted to specific organelles including endoplasmic reticulum Golgi apparatus lysosome by protein targeting While some proteins are not associated with the signal peptide a Lysosome targeting of protein occurs in Cis Golgi network CGN NAcetyl glucosamine NAG phosphorylases first binds to Mannose residues The NAG part is then removed and    See Answer
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