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Q3. During the lectures of Part-14, you learned that anti-CD20 antibodies coupled with a potent-toxin may...

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Medical Sciences

Q3. During the lectures of Part-14, you learned thatanti-CD20 antibodies coupled with a potent-toxin may be used tokill tumor B cells.

Suppose that CD20 is expressed on by hematopoietic stemcells and all the developmental stages of B cells.

Do you think that in this case, anti-CD20 antibodiescoupled with a potent-toxin can still be used to kill B cell tumorcells?

Yes, No….please explain why.

Answer & Explanation Solved by verified expert
4.0 Ratings (577 Votes)
CD20 is surface Bcell marker CD20 is a general B cell marker that is expressed during B cell differentiation from the proB cell phase until the plasma cell stadium Yes antiCD20antibodies coupled with a potenttoxin can still be used to kill B cell tumor cells because Therapeutic monoclonal antibodies mAbs that target the CD20 antigen on B cells are successfully used in the clinic for the depletion of B cells to treat various forms of cancer and autoimmune diseasesCD20 mAbs can induce tumor killing via various mechanisms such as direct induction of apoptosis    See Answer
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