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Prior to a fatty acid (FA) being used as the input for beta-oxidation, it is activated...

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Biology

Prior to a fatty acid (FA) being used as the input forbeta-oxidation, it is activated and transitions from cytosol tomitochondria.

How is the FA activated and how is the activated FA is sent tothe mitochondria matrix. Also explain how the breaking down of theFA in B-oxidation ends up producing big amounts of ATP (need todescribe multiple metabolic reactions here)

Answer & Explanation Solved by verified expert
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Fatty acids FA are activated before they enter the mitochondrial matrix Prior to activation FA must be linked to CoA to form fatty acyl CoA This reaction takes place in the outer membrane of the mitochondrial matrix Adenosine triphosphate ATP drives the formation of fatty acyl CoA Fatty acyl CoA is formed by the thioester linkage between the carboxyl group COOH of a fatty acid and the sulfhydryl group SH of CoA yield AMP and pyrophosphate PPi The reaction is catalyzed by the    See Answer
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