predict what would happen if the tyrosines in the activation loop of insulin were mutated to...

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Medical Sciences

predict what would happen if the tyrosines in theactivation loop of insulin were mutated to phenylalanine
phenylalanines will likely be phosphorylated butinsulin recptor will not be activated
phenyalanines cannot be phosphorylated and insulinwould not be activated
phenylalanine will likely be phosphorylated and irs 1will bind and be phosphorylated
phenylalanine cannot be phosphorylated but irs 1 willbind and be phosphorylated

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Insulin receptor is a receptor tyrosine kinase family of receptors It binds to insulin a hormone that is involved in control of blood sugar levels Insulin binds to two sites on each of the two receptors This leads to crosslinking of the tow receptors by insulin forming a dimer Receptor dimerization will activate autophosphorylation of three tyrosine residues on the beta subunit of the receptor by tyrosine kinase The receptor tyrosine kinase domain is formed by two lobes N and C See Answer

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