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Poisonous nerve gases such as sarin work by breaking down AChE (acetylcholinesterase) at nerve-muscle synapses. What...

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Medical Sciences

Poisonous nerve gases such as sarin work by breaking down AChE(acetylcholinesterase) at nerve-muscle synapses. What do you thinkis the effect of nerve gas on the muscles? Why? Be sure to includea discussion of the steps that occur in the nerveand motor end plate during transmission at theneuromuscular junction and the role of AChE in normal synaptictransmission. Propose a way to counteract the effects of nerve gas(besides getting rid of the gas itself).

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Answer 1 Normally acetycholine around synapse is responsible for contrqction of muscles Acetycholine is destroyed by acetycholinesterases into choline and acetate There are drugs like anticholinesterases which destroy acetycholinesterases and result in accumulation of Acetycholine around synapses As acetycholine is not destroyed by cholinesterases because of ita destruction by anticholinesterases Nerve gases like Sarin are Organophosphate which cause Irreversible inhibition of Anticholinesterases So accumulation of Acetylcholine occur around synapse Acetylcholine is cholinergic drug causing contraction of muscles This causes excessive stimulation of muscarinic    See Answer
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