Please explain the following:
Understand the family of TGF beta signaling molecules
(ligands).
Understand that the TGF beta...
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Biology
Please explain the following:
Understand the family of TGF beta signaling molecules(ligands).
Understand that the TGF beta superfamily of growth factorligands are synthesized and secreted in an Inactive form, and needto be activated extracellularly by proteolytic cleavage.
Understand the structure of the bioactive form of TGF beta.
Understand the family of TGF beta receptor structure andfunction
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TGF beta signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo The TGF beta family includes TGF beta 1 TGF beta 2 and TGF beta 3 TGF betas are involved in embryogenesis and cell differentiation as well as apoptosis They bind to TGF beta receptor type II TGFBR2The TGF beta superfamily of ligands include Bone morphogenetic proteins BMPs Growth and differentiation factors GDFs Anti mullerian hormone AMH Activin Nodal and TGFBs Signalling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor The type II receptor is a serinethreonine receptor kinase which catalyzes the
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