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please answer the following regarding Mutation Why do methylated cytosines produce hotspots for mutation? What happens if...

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Biology

please answer the following regarding Mutation

Why do methylated cytosines produce hotspots for mutation?

What happens if an insertion or deletion mutation does notconsist of a multiple of three nucleotides? What is thiscalled?

What is “polarity” in relation to these gene mutations?

Mutations outside the coding sequence can speed up or slow downtranscription. What are these mutations called and which is which?What is a “position effect”?

Answer & Explanation Solved by verified expert
3.7 Ratings (375 Votes)
5Methylcytosine in DNA is genetically unstable Methylated CpG mCpG sequences frequently undergo mutation resulting in a general depletion of this dinucleotide sequence in mammalian genomes Unmethylated C deaminates to uracil spontaneously and this is corrected by the mismatch repair machinery because uracil is not a DNA nucleotide Methylated C deaminates to thymidine here the mismatch    See Answer
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