please answer the following regarding Mutation Why do methylated cytosines produce hotspots for mutation? What happens if...

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Biology

please answer the following regarding Mutation
Why do methylated cytosines produce hotspots for mutation?
What happens if an insertion or deletion mutation does notconsist of a multiple of three nucleotides? What is thiscalled?
What is â€œpolarityâ€ in relation to these gene mutations?
Mutations outside the coding sequence can speed up or slow downtranscription. What are these mutations called and which is which?What is a â€œposition effectâ€?

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5Methylcytosine in DNA is genetically unstable Methylated CpG mCpG sequences frequently undergo mutation resulting in a general depletion of this dinucleotide sequence in mammalian genomes Unmethylated C deaminates to uracil spontaneously and this is corrected by the mismatch repair machinery because uracil is not a DNA nucleotide Methylated C deaminates to thymidine here the mismatch See Answer

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