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Pick a protein of interest.->insulin Use the Blast tool to find protein homologs of your protein...

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Biology

Pick a protein of interest.->insulin

Use the Blast tool to find protein homologs of your protein andsubmit blast search.

Use the multalign tool to align five of the homologs and submitalignment.

Identify conserved amino acids and regions of homology.

Find a PDB for your protein or one of the homologs. If yourprotein has not been examined structurally. (Start Again)

Use Jmol to evaluate your proteins 3D structure and answer thefollowing questions.

How many subunits in your protein?

Does your protein have any cofactors or coenzymes?

How many amino acids residues in one of the subunits of yourprotein?

How many amino acids interact at the interface of the subunitsof your protein?

Does your protein have an active site or ligand binding domainand what are the key amino in that region.  

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