pH Dependence of Drug Absorption lab 1. Calculate the amount of Na2HPO4 * 7H2O ( in grams)...

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Chemistry

pH Dependence of Drug Absorption lab
1. Calculate the amount of Na₂HPO_{4 }7H₂O ( in grams) needed to make 50 mL of a 0.40 Msolution.
2. Calculate the amounts of Na₂HPO₄ andNaH₂PO₄ (in grams) needed to prepare 200 mLof a buffer with pH=8.25 so that the sum of concentrations ofHPO₄^2- andH₂PO₄^- ions is 0.5 M.pK_a1=2.12, pK_a2=7.21, pK_a3=12.38
on this problem I think you use the Henderson-Hasselbalchequation, but after that I'm lost.
3. Write the equation for the ionization of 3-aminophenol. Wouldthis substance be more soulble in water at pH=2 or pH= 8? Would youexpect this substance to be absorbed into the blood stream in thestomach or the instestines?
4. How does the initensity of the spot on the silica sheetrelate to the solubility of the drug in the aqueous phase?
Please explain the the problems!!

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4.5 Ratings (945 Votes)

1 First we calculate the number of moles required moles M x V 040 molL x 0050 L 002 moles With this and the molecular weight MW 2x23 31 5x16 8x1 165 gmol m 165 gmol x 002 mol 33 g 2 You a re right you need to use the See Answer

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