Part1:
Use the information from outside resources about HGPS
(Hutchinson-Gilford-progeria-syndrome) to answer the questions
below.
Explain why the lamin...
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Biology
Part1:
Use the information from outside resources about HGPS(Hutchinson-Gilford-progeria-syndrome) to answer the questionsbelow.
Explain why the lamin A mutation is classified as adominant-negative mutation.
What treatment do scientists develop to ameliorate the symptomsof HGPS in fibroblasts?
How did scientists use CRISPR to treat progeria?
Part 2:
Define the following terms:
LAP2
HP1
Tri-Me-K9
Cryptic splice site
Morpholino oligonucleotide
Adeno-associated virus 9 (AAV9)
CRISPR
Cas9
Answer & Explanation
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1 HGPS is HutchinsonGilford Progeria syndrome This results in old age like characteristics It is a genetic disorder Autosomal dominant observed in children caused by mutation in LMNA gene Dominant refers to dominant allelic effect Negative mutation is described by loss of specific protein or parts of proteins causing loss of fuction LMNA genes are responsible for providing instructions for generation proteins Lamins Lamin protein functions in determining the shape of nucleus in a cell In HGPS the different form dominant negative of lamin protein called
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