Part A. A neutrophil is chasing a pathogenic bacterium. Explain how it will detect and move...

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Medical Sciences

Part A. A neutrophil is chasing a pathogenic bacterium. Explainhow it will detect and move toward its prey and how it will changecourse when necessary.
Part B. A mutation that destroys the GTPase function of Ras isan initiating event in many cancers. Describe how constantactivation of Ras will cause increased expression of Cyclin D and Sphase genes by the transcription factor E2F.
Part C. When the transcription factor E2F is activated, it canamplify its own gene expression and leads to the transcription ofCyclin E. Cyclin E with Cdk2 can phosphorylate Rb, removing theRbâ€™s inhibitory effect on E2F. These are two positive feedbackloops that occur in E2F activation. What do you think is the effectand purpose of these two feedback loops?Â Â

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Answer Part A Neutrophils plays a major role in innate immune system Neutrophils gets produced and matured in the bone marrow When bacteria infects the body then neutrophils gets recruited from the bloodstream to the site of bacterial See Answer

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