Part 1:

1) What is genetics?

2) What is a karyotype?

3) What are chromosomes? (Include how many chromosomes humanshave and what autosomes and sex chromosomes are.)

4) What is a gene?

5) What do the terms “allele” and “homologue” mean?

6) What do we mean by the following terms:

a. Homozygous trait

b. Heterozygous trait

c. Dominant gene

d. Recessive gene

7) What do the terms “genotype” and “phenotype” mean?

8) Briefly explain the three factors that contribute togenetic variability.

a. Independent assortment

b. Crossover of homologues

c. Random fertilization

9) Briefly describe the following. Provide an example foreach.

a. Dominant-recessive inheritance

b. Incomplete dominance inheritance

c. Multiple-allele inheritance

d. Sex-linked inheritance

e. Polygene inheritance

f. Extranuclear (mitochondrial) inheritance (not really apattern

10) What role, if any, do environmental factors play in geneexpression?

11) What is genetic screening? Why do they determinepedigrees?

12) Compare/contrast amniocentesis and chorionic villussampling (including the benefits and risks associated witheach).

Part 2:

1) What do we mean when we use the expression “the humangenome”?

2) By what percentage does the human genome differ from personto person?

3) How many genes are there in the human genome?

4) Define:

a. exons

b. introns

c. structural genes

d. regulator genes

e. satellite DNA

5) What is gene therapy?

6) What is meant by the terms “in vivo” and “ex vivo” as theyapply to gene therapy?

7) Name two “tools” used in gene therapy indicating where theyare most used (relative to the terms asked about in item 6above).

8) Name two diseases/disorders where gene therapy has enjoyedsome success.

9) What are two big challenges for gene therapy?

10) How do you feel about gene therapy? (There is no right orwrong answer here.)