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Parents of a kidney transplant candidate were tested for a potential compatible kidney because the candidate...

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Biology

Parents of a kidney transplant candidate were tested for apotential compatible kidney because the candidate demonstrated HLAantibodies. The patient's HLA antigens were typed as A1, A2, B27,B50, DR17, and DR11. Antibodies identified were specific for A3,B18, and DR7 antigens.

1.  If the mother's HLA typingis A1,A3, B35, B27, DR4, and DR11, and the father's typing is A2, A24,B50, B44, DR11, and DR17, what antigens did the fathercontribute?

2. List the probable HLA types of the candidate's threesiblings. Select the kidney or kidneys with the best match.

Answer & Explanation Solved by verified expert
4.3 Ratings (498 Votes)
MHC genes contain 33 to 44 genes grouped in 3 regions class I Class II and class III Class A has HLAA HLAB and HLAC molecules Class II has HLADr HLADP and HLADQ and class II includes complement proteins C3 and C4 and cytokines There is linkage disequilibrium as most genes are linked    See Answer
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