NMR measurements have shown that poly-L-lysine is a random coil
at pH=7 but becomes alpha helical...
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Chemistry
NMR measurements have shown that poly-L-lysine is a random coilat pH=7 but becomes alpha helical as the pH is raised above 10.
a) Why can NMR give this sort of information? (what exactly doesNMR look at?)
b) what may be causing this pH-dependent transition?
c) predict the pH dependence of a helix-coil transition if thepoly-L-aspartate
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4.5 Ratings (771 Votes)
a Electrostatic repulsion between positively charged aminogroups hinders helix formation at pH 7 At pH 10 the side chainsbecome deprotonated allowing helix formationThe alpha helix helix is acommonsecondary structure of proteins and is a righthandcoiled orspiral conformation helix in which every backbone NHgroupdonates a hydrogen bond to the backbone CO group of the aminoacidfour residues earlier
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