ndicate whether each of the following 5 statements (a-e) is TRUEor FALSE.  If you think a statement is FALSE, explainexactly what is incorrect and provide the correct information.

a.  TRUE / FALSE   In treating B cellleukemia, chimeric antigen receptor (CAR) T cells function bybinding to a B cell specific antigen, such as CD19, in the form ofa peptide presented on MHC

b.  TRUE / FALSE    CAR T cellsexpress a chimeric antigen receptor that is composed of a TCRextracellular domain and a CTLA-4 intracellular domain

c.  TRUE / FALSE   Many tumors expressPD-L1 which enables tumor-infiltrating T cells that express PD1 torecognize the tumor cells and destroy them.

d.  TRUE / FALSE   Oncolytic virusimmunotherapy involves: 1) selective viral infection of tumorcells, resulting in tumor cell death, and 2) the induction of localinflammation, leading to an amplification of systemic anti-tumorimmune responses, resulting in elimination of uninfected metastatictumors.

e.  TRUE / FALSE   In adoptive celltherapy for cancer, immune cells are harvested from a patient,activated in vitro or genetically engineered to enhancetheir anti-tumor activity, then injected back into thepatient.  Such cells can be used to treat other patientswith the same type of cancer.