Muscular Dystrophy (BMD), and an individual with DuchenesMuscular Dyst...

Muscular Dystrophy (BMD), and an individual with Ducheneâ€™s Muscular Dystrophy (DMD). DNA Sequence (1141-1200 bp) WT#1 cagaatgaa gcagagcca gagtttgct...

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Biology

Muscular Dystrophy (BMD), and an individual with Ducheneâ€™sMuscular Dystrophy (DMD).
DNA Sequence (1141-1200 bp)
WT#1
cagaatgaa gcagagcca gagtttgct tcgagactt gacacggaa ctcaaagaacttaac
WT#2
aagaatgaa gctgagcca gagttcgct tcgagactt gacacagaa ctgaaagaacttaac
WT#3
aagaatgaa gcagagcca gagtttgct tcgagaatt gagacagaa ctcaaagaacttaac
BMD
aagaatgaa gctgagcca gagtttgct tcgagactt gagacagaa ctcaaagaacttaac
DMD
aagaacgaa gcagagcca gagattgct tagagaatt gacacggaa ctcaaagaacttaac
DNA Sequence (1201-1260bp)
WT#1
actcagtgg gatcacatg tgccaacag gtatagaca atctctttc actgtcgctagcctc
WT#2
acgcagtgg gatcatatg tgccaacag gtatagaca atctccttc actgtggctagcctc
WT#3
acgcagtgg gatcacatg tgccaacag gtatagaca atctccttc actgtcgcttgcttc
BMD
accagtggg accacatgt gccaacagg tatagacaa tctctttca ctgtggcttgcttca
DMD
actcagtgg gaccatatg tgccaacag gtatagaca atctctttc actgtggctagcctc
6.What type(s) of mutations are there between the BMDstrand and the WT strands. What effects, if any, do you think thesemutations have on the function of the dystrophin protein. Explainyour reasoning. (Assume that the observed mutations ONLY affect thepolypeptide sequence in this exon.)

Answer & Explanation Solved by verified expert

4.1 Ratings (659 Votes)

The DNA sequences were subjected to ClustalW alignment Theresults are as followsThe site marked with 1 indicates a deletion of nucleotideThis deletion leads to frameshift mutation ie See Answer

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