Methanol and ethanol are both oxidized by alcohol dehydrogenase (ADH). Methanol is poisonous because it is...

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Methanol and ethanol are both oxidized by alcohol dehydrogenase(ADH). Methanol is poisonous because it is oxidized by ADH to formthe highly toxic compound formaldehyde. The adult body has 40 L ofwater, throughout which these alcohols are rapidly and uniformlydistributed. The densities of both alcohols are 0.79 g/mL. The Kmof ADH for ethanol is 1.0x10-3 M, and for methanol the Km is1.0x10-2 M. The molecular mass of methanol is 32 g/mol and that ofethanol is 46 g/mol. If an individual consumed 100 mL of methanol(a leathal amount), how much 100-proof whiskey (50% ethanol byvolume) must this person consume in order to reduce the activity ofADH toward methanol to 5%? Assume the Ki for ethanol = Km.

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The enzyme catalyzed reaction that takes place isE S ES E Pwhere E is enzyme alcohol dehydrogenaseADH S issubstratemethanol and P is the productformaldehyde Ethanol isused as an inhibitor IAccording to MichaelisMenten kinetics the reaction velocity ofmethanol conversion is given asv VmaxS KmSwhen inhibitor I is added the velocity becomesv2 See Answer

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