Limb Development. Different species display characteristic digit patterning along the anterior-posterior axis. The forelimbs of bats are...

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Biology

Limb Development.
Different species display characteristic digit patterning alongthe anterior-posterior axis. The forelimbs of bats are modifiedsuch that the posterior digits are elongated and maintain theirwebbing (to make the functional bat wing). Researchers observedthat in addition to the normally timed expression of Sonic hedgehog(Shh) in the bat ZPA, there is a second phase of both Fgf8 and Shhexpression in the developing forelimb in the interdigitaltissue.
How does the second phase of Fgf8 and Shh contribute to both theelongation of the forelimb digits and to the maintenance of thewebbing between the digits?

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Sonic hedgehog pathway is involved in unique skeletal development of the limbs in bats The processes involved in anteriorposterior patterning and development of limb buds require changes in Shh pathway Anteriorposterior AP patterning of limbs and the size of digits are different in bats as compared to mouse In bats the forelimbs have elongated posterior digits that are joined by tissue webbing along with short thumbs On the other hand the digits of hindlimb do not vary in size Shh is widely expressed in the zone of polarizing ZPA activity This early Shh expression occurs with fibroblast growth factor 8 See Answer

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