Jean is a 34 year-old woman who is pregnant for the first time. She has a...

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Biology

Jean is a 34 year-old woman who is pregnant for the first time.She has a sister who had spina bifida and an older brother who hada stroke when he was 14. Jean has tested positive for presence of agenetic defect known as 677C>T in the methylene-tetrahydrofolatereductase (MTHFR). She is worried about using the traditionalprenatal vitamin-mineral supplement because she has been cautionedthat she is unable to metabolize folic acid from diet andsupplements. She is asking for your advice for a successfulpregnancy.
Nutrition Diagnostic Statement
Altered nutrient (folic acid) metabolism related to a geneticalteration as evidenced by positive results for 677 C>T in theMTHFR gene and having a family history of spina bifida and stroke.Nutrition Care
What advice would you give Jean about any additional dietary andlifestyle changes to consider?

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4.0 Ratings (443 Votes)

The folic acid from diet or supplement should be converted to Lmethylfolate by a series of reaction in our systemDHF Dihydroxy folateTHF trihydroxy folateDHFR Dihydroxy folate reductaseMTHFR See Answer

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