Influenza viruses gain entry into their host cells by attachment to N-acetylneuraminic acid residues on the...

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Biology

Influenza viruses gain entry into their host cells by attachmentto N-acetylneuraminic acid residues on the cell surface, followedby receptor-mediated endocytosis. What effect would the followingtreatments have on attachment of the virion to a susceptiblecell.
i.Treatment of the susceptible cell with neuraminidase
ii.Treatment of the susceptible cell with NH4 Cl to preventlowering of lysosomal pH
iii. Treatment of the susceptible cell with actinomycin D, whichprevents synthesis of messenger mRNA
b. What effect would these same treatments have on uncoating ofthe virion?
C. What effect would each of these treatments have on the burstsize of an influenza infection?

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Answer i Since sialic acid is required for attachment to host cell and neuraminidase bind and cleave sialic acid treatment with neuraminidase will remove surface sialic acid resulting in loss of influenza binding ii After binding and entry via endocytosis influneza virus needs to release its genome into cytosol of host cell which will be imported to nucleus for See Answer

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