Individuals with diabetes mellitus have an increased risk for developing kidney disease due to accumulated damage...

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Individuals with diabetes mellitus have an increased risk fordeveloping kidney disease due to accumulated damage to thenephrons. Based on our discussion of filtration, explain how an ACEinhibitor may prevent damage to the kidney individuals withdiabetes. Explain how an ACE inhibitor works, what blood vessel(s)and any other structures that would be directly impacted by an ACEinhibitor, and how treatment with an ACE inhibitor could preventdamage to the nephrons.

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Ans MECHANISM OF ACE INHIBITORSACE inhibitor s abolishes the pressor action of Ang I but not that of Ang II does not block AT1 or AT2 receptors ACE is a relatively nonspecific enzyme splits off a dipeptidyl segment from several peptides including bradykinin substance P etc in addition to Ang I As such captopril increases plasma kinin levels and See Answer

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