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In which direction do you think the pKa of aspartate would shift when it is buried...

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Biology

In which direction do you think the pKa ofaspartate would shift when it is buried in the hydrophobic interiorof a protein, and does not form an ion pair with a positivelycharged group? Explain in 1-2 sentences.

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4.3 Ratings (653 Votes)
In general the pKa values of internal groups in proteins are shifted relative to the normal pKa values in water This coupling between pKa and protein conformation is responsible for the pH dependence    See Answer
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