In the EOG module, we explored how myasthenia gravis results in problems in nerve conduction. How...

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Medical Sciences

In the EOG module, we explored how myasthenia gravis results inproblems in nerve conduction. How does the mechanism for reducednerve conduction in myasthenia gravis compare to the mechanismresulting in reduced nerve conduction that we see in multiplesclerosis?Â Â

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mechanism for reduced nerve conduction in myasthenia gravis Myasthenia gravis MG is the most common primary disorder of neuromuscular transmission The usual cause is an acquired immunological abnormality but some cases result from genetic abnormalities at the neuromuscular junction The normal neuromuscular junction releases acetylcholine ACh from the motor nerve terminal in discrete packages quanta The ACh quanta diffuse across the synaptic cleft and bind to receptors on the folded muscle endplate membrane Stimulation of the motor nerve releases many ACh quanta that depolarize the muscle endplate region and then the muscle membrane causing muscle contraction See Answer

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