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In molecular biology, two identical molecules with different linking number are said to be topoisomers. Describe...

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Biology

In molecular biology, two identical molecules withdifferent linking number are said to be topoisomers. Describe how acircular DNA molecule can be converted from one topoisomer intoanother if there are no free ends?   

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In the case of closed circular double stranded DNA molecules the linking number cannot change because the two ends of the DNA molecule are covalently linked ie there are no free ends to rotate about each other in space So these types of molecules cannot change the linking number without a chain break Unwinding or overwinding without chain break cause torsion within the molecule and to accommodate this torsion the molecule supercoils Supercoils are introduced into DNA when a duplex is    See Answer
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