In many cancer cell lines, PDH kinase (PDK) activity is increased. The result of this regulation...

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In many cancer cell lines, PDH kinase (PDK) activity isincreased. The result of this regulation is that pyruvate isdirected towards a pathway other than the TCA cycle. Once again,using your excellent research skills, explain the reason cancercells might direct pyruvate to an alterative pathway and whatadvantage this might provide to cancer cells

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1 Cancer cells oxidize a decreased fraction of the pyruvate generated from glycolysis 2 The mitochondrial pyruvate carrier MPC composed of the products of the MPC1 and MPC2 genes modulates fractional pyruvate oxidation MPC1 is deleted or underexpressed in multiple cancers and correlates with poor prognosis 3 Cancer cells tend to express a partially inhibited splice variant of pyruvate kinase PKM2 leading to decreased pyruvate production 4 The two proteins that mediate pyruvate conversion to lactate and its export Mtype lactate dehydrogenase and the monocarboxylate transporter MCT4 are commonly upregulated in cancer cells leading to decreased See Answer

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