In many assays the K65A RT mutant shows a reduction in RT activity. using the structure papers,...

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Biology

Inmany assays the K65A RT mutant shows a reduction in RT activity.using the structure papers, explain the reasoning behind thisphenotype

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The reverse transcriptase RT of HIV1 is a multifunctional chemical that catalyzes the change of viral genomic RNA into twofold stranded proviral DNA RT is a vital focus for antiviral chemotherapy since it is fundamental for viral replication Two classes of inhibitors are right now being utilized as a part of the administration of HIV disease Nonnucleoside RT inhibitors NNRTIs tie specifically to a hydrophobic pocket contiguous the polymerase dynamic site of RT Nucleoside RT inhibitors NRTIs for example zidovudine AZT and lamivudine 3TC which are in effect broadly utilized as a part of the treatment of HIV contamination act by contending with characteristic substrates at the HIV RT dynamic site prompting joining and end of the DNA chain Dissimilar See Answer

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