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In humans, the huntingtin gene is essential for nerve cells to function effectively. People with Huntington’s...

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Biology

In humans, the huntingtin gene is essential for nerve cells tofunction effectively. People with Huntington’s disease have 2different copies of the huntingtin gene – one normal and onemutated. The mutated huntingtin gene (HD) is caused by an excess ofcodons (CAG) that code for the amino acid glutamine. The HD gene isresponsible for deterioration of the nerve cells, which leads toloss of one’s ability to move, feel and think.

Can you design an RNAi drug that targets only the HD gene andnot the normal huntingtin gene?

Answer & Explanation Solved by verified expert
3.7 Ratings (487 Votes)
Lets look at the scenario again a bit clearly People with Huntingtin disease have two copies alleles of the Huntingtin gene namely mutated Huntingtin allele HD and Normal allele lets call it NHD The key to solve this question is the fact that mutated HD    See Answer
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