In familial retinoblastoma, are mutations in thenormal RB1 gene always responsible forthe loss of heterozygosity?
In a family with retinoblastoma, would the mechanism ofloss of heterozygosity in tumors in different members of the familybe expected to be same or different?
Cite some evidence supporting the conclusion that tumorcells are clonal.
A gene for hereditary prostate cancer has been mapped tochromosomal location 1q25; it shows autosomal dominant inheritance.How would you go about identifying the mutant gene?
What would be the expected result of nonsense mutationin Mad gene?
Would the mutation in the gene for Cdc20 proteinexpected to be dominant or recessive?
