In familial retinoblastoma, are mutations in the normal RB1 gene always responsible for the loss of heterozygosity? In...

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Biology

In familial retinoblastoma, are mutations in thenormal RB1 gene always responsible forthe loss of heterozygosity?
In a family with retinoblastoma, would the mechanism ofloss of heterozygosity in tumors in different members of the familybe expected to be same or different?
Cite some evidence supporting the conclusion that tumorcells are clonal.
A gene for hereditary prostate cancer has been mapped tochromosomal location 1q25; it shows autosomal dominant inheritance.How would you go about identifying the mutant gene?
What would be the expected result of nonsense mutationin Mad gene?
Would the mutation in the gene for Cdc20 proteinexpected to be dominant or recessive?

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1 The retinoblastoma gene is a normal tumor supressor gene Therefore mutations in the normal RB1 gene is always responsible for the loss of heterozygosity and the devlopment of retinoblastoma 2 The See Answer

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