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In class, we discussed how H146 of the β -chain of normal adult hemoglobin ends up...

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Biology

In class, we discussed how H146 of the β -chain ofnormal adult hemoglobin ends up in close proximity toD94 on the same chain when oxygen is delivered to thetissues. In hemoglobin Hiroshima, however, H146on the β -chain has been changed to a D through mutation. Whateffect, if any, does this mutation have on the Bohr Effect of thismutant hemoglobin?

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diminishes the H+ portion of the Bohr Effect

increases the H+ portion of the Bohr Effect

has no effect on the CO2 portion of the Bohr Effect

increases the CO2 portion of the Bohr Effect

has no effect on the H+ portion of the Bohr Effect

diminishes the CO2 portion of the Bohr Effect

Answer & Explanation Solved by verified expert
4.5 Ratings (585 Votes)
Answer In hemoglobin Hiroshima however H146 on the chain has been changed to a D through mutation Bohr Effect of this mutant hemoglobin are 1 diminishes the H portion of the Bohr Effect 2 diminishes the CO2 portion of the Bohr Effect Explanation Histidine present at 146 position of beta chain of haemoglobin contributes to the alkaline Bohr effect This interaction is disrupted in Hb Hiroshima 146 His Asp    See Answer
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