In class, we discussed how H 146 of the chain ofnormal adult hemoglo...

In class, we discussed how H146 of the Î² -chain of normal adult hemoglobin ends up...

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Biology

In class, we discussed how H₁₄₆ of the Î² -chain ofnormal adult hemoglobin ends up in close proximity toD₉₄ on the same chain when oxygen is delivered to thetissues. In hemoglobin Hiroshima, however, H₁₄₆on the Î² -chain has been changed to a D through mutation. Whateffect, if any, does this mutation have on the Bohr Effect of thismutant hemoglobin?
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Group of answer choices
diminishes the H+ portion of the Bohr Effect
increases the H+ portion of the Bohr Effect
has no effect on the CO2 portion of the Bohr Effect
increases the CO2 portion of the Bohr Effect
has no effect on the H+ portion of the Bohr Effect
diminishes the CO2 portion of the Bohr Effect

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Answer In hemoglobin Hiroshima however H146 on the chain has been changed to a D through mutation Bohr Effect of this mutant hemoglobin are 1 diminishes the H portion of the Bohr Effect 2 diminishes the CO2 portion of the Bohr Effect Explanation Histidine present at 146 position of beta chain of haemoglobin contributes to the alkaline Bohr effect This interaction is disrupted in Hb Hiroshima 146 His Asp See Answer

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