In building a profile for a set of sequences, PSI BLAST weighs sequences differently. Why is...

90.2K

Verified Solution

Question

Civil Engineering

In building a profile for a set of sequences, PSI BLAST weighssequences differently. Why is this done?
What are pseudocounts and why are they used?

Answer & Explanation Solved by verified expert

4.2 Ratings (758 Votes)

BLAST BLAST Basic Local Alignment Search Tool is a sequence similarity search method in which a query protein or nucleotide sequence is compared to nucleotide or protein sequences in a target database to identify regions of local alignment and report those alignments that score above a given score threshold PSIBLAST PositionSpecific Iterative PSIBLAST is a protein sequence profile search method that builds off the alignments generated by a run of the BLASTp program The first iteration of a PSIBLAST search is identical to a run of BLASTp program PSIBLAST is most conveniently used on the internet with the help of the graphical See Answer

Get Answers to Unlimited Questions

Join us to gain access to millions of questions and expert answers. Enjoy exclusive benefits tailored just for you!

Membership Benefits:

Unlimited Question Access with detailed Answers
Zin AI - 3 Million Words
10 Dall-E 3 Images
20 Plot Generations
Conversation with Dialogue Memory
No Ads, Ever!
Access to Our Best AI Platform: Flex AI - Your personal assistant for all your inquiries!

Become a Member