Immunology How does Indo1 allow measurement of signaling in real time? What is store operated calcium entry...

80.2K

Verified Solution

Question

Biology

Immunology
How does Indo1 allow measurement of signaling in real time? Whatis store operated calcium entry and how is it regulated?
If the EF-hand domain was mutated so it behaved like it wasalways bound to calcium how would this impact signaling?
Give 2 examples of inhibitory receptors that regulate T cellfunction How does CTLA4 reduce signaling in T cells?
Describe 3 ways that Fas/FasL interactions regulate T cellmediated immune responses

Answer & Explanation Solved by verified expert

3.6 Ratings (661 Votes)

Calcium is an important second messenger and Indo1 is a Calcium sensitive fluorophore with the excitation wavelength in the UV range So When excited the emitted fluorescence is measured which can be used in the detection of Ca2 levels in real time Storeoperated calcium entry is a ubiquitous Ca2 entry pathway that is activated upon the stimulation of plasma membrane receptors which are coupled to PIP2 See Answer

Get Answers to Unlimited Questions

Join us to gain access to millions of questions and expert answers. Enjoy exclusive benefits tailored just for you!

Membership Benefits:

Unlimited Question Access with detailed Answers
Zin AI - 3 Million Words
10 Dall-E 3 Images
20 Plot Generations
Conversation with Dialogue Memory
No Ads, Ever!
Access to Our Best AI Platform: Flex AI - Your personal assistant for all your inquiries!

Become a Member