Immunology
Describe 2 ways that ubiquitinylation regulates signaling eitherpositively or negatively.
What is the role of guanine nucleotide exchange factors ininitiating signaling and what kind of signaling pathway do theyinitiate?
What is the target of LCK on the CD3 molecule and how does thatinfluence the initiation of signaling when the TCR bindsantigen?
Distinguish the roles of SH3 ligands and CD45 in the regulationof SRC family kinases
Explain how PLCgamma is activated and what the outcome of thatactivation produces.
What three transcription factors enter the nucleus whensufficient TCR signaling occurs and how does that lead to clonalexpansion of antigen specific T cells?
