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If the GTPase function of Ras is destroyed, Ras will always be on/activated. This causes increased...

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Biology

If the GTPase function of Ras is destroyed, Ras will always beon/activated. This causes increased Cyclin D and S phase genesexpression by transcription factor E2F. Describe how thisactivation of Ras causes this increased expression of both Cyclin Dand S phase genes by explaining the role/function of thefollowing:

  • Raf, MEK, ERK
  • Myc
  • Cyclin D/Cdk4 or Cdk 6
  • Rb
  • E2F

also indicate if any of the above are a kinase or transcriptionfactor

Answer & Explanation Solved by verified expert
4.1 Ratings (805 Votes)
Solution The retinoblastoma Rb is a tumor suppressor protein that inhibits the specialized transcription factor E2F during the progression of cell cycle When E2F is free they can activate G1S transition cyclins    See Answer
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