If the GTPase function of Ras is destroyed, Ras will always be
on/activated. This causes increased...
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Biology
If the GTPase function of Ras is destroyed, Ras will always beon/activated. This causes increased Cyclin D and S phase genesexpression by transcription factor E2F. Describe how thisactivation of Ras causes this increased expression of both Cyclin Dand S phase genes by explaining the role/function of thefollowing:
Raf, MEK, ERK
Myc
Cyclin D/Cdk4 or Cdk 6
Rb
E2F
also indicate if any of the above are a kinase or transcriptionfactor
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Solution The retinoblastoma Rb is a tumor suppressor protein that inhibits the specialized transcription factor E2F during the progression of cell cycle When E2F is free they can activate G1S transition cyclins
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