If a histidine sidechain in a binding site is protonated in the free protein, but deprotonated...
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Chemistry
If a histidine sidechain in a binding site is protonated in thefree protein, but deprotonated in the ligand-bound state, how wouldpH affect the interaction?
A.) No effect
B.) Lower Kd at lower pH
C.) Higher Kd at lower pH
D.) Only ΔH would change with pH
If a histidine sidechain in a binding site is protonated in thefree protein, but deprotonated in the ligand-bound state, how wouldpH affect the interaction?
A.) No effect
B.) Lower Kd at lower pH
C.) Higher Kd at lower pH
D.) Only ΔH would change with pH
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