Hydrogen bonds can form with bases on the opposite DNA strands in the double helix, or...

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Biology

Hydrogen bonds can form with bases on the opposite DNAstrands in the double helix, or between the bases and H2O in thesingle stranded conformation. Considering that the double helix isthe most stable conformation in water, how does this observationsupport the conclusion that base stacking contributes more to helixstability than interbase hydrogen bonding?Hydrogen bonds can formwith bases on the opposite DNA strands in the double helix, orbetween the bases and H2O in the single stranded conformation.Considering that the double helix is the most stable conformationin water, how does this observation support the conclusion thatbase stacking contributes more to helix stability than interbasehydrogen bonding?

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AnswerThe stability of DNAdepends on hydrogen bonds that are formed with bases on theopposite DNA strands in the double helix or between the bases andH2O in the single stranded conformationDNA duplex stabilitydepends primarily by hydrogen bonding but base stackingcontributes more to helix stability than interbase hydrogenbondingFirst we consider hydrogen bondingThe bases ofsinglestranded DNA are heterocyclic and See Answer

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