Human cells contain a protein that binds to the 5? triphosphate
groups of RNA. Explain why...
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Human cells contain a protein that binds to the 5? triphosphategroups of RNA. Explain why this protein would be part of thedefense against viral infection.
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The ATPase retinoid acidinducible gene RIGI senses viral RNA in the cytoplasm of infected cells and subsequently activates cellular antiviral defense mechanisms RIGI recognizes molecular structures that discriminate viral from host RNA Viral infections are sensed by patternrecognition receptors PRRs of the innate immune system that recognize pathogenassociated molecular patterns PAMPs and trigger antiviral gene programs including the production of IFN typeI Viral RNA serves as a PAMP and can be recognized by tolllike receptor TLR3 TLR78
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