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how to increase a binding between a ligand ( etravirine) and a protein ( Human immunodeficiency virus...

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Chemistry

howto increase a binding between a ligand ( etravirine) and a protein( Human immunodeficiency virus type 1 HIV-1). disscusion should bebased on thermodynamic theory

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Ligands that bind to the allosteric site impair enzyme action by a wedge mechanism they hinder domain mobility opening and closing access to the active site Final allosteric site architecture is achieved upon binding of the ligand This flexibility and the possible clash between protein and ligand was accounted for by using a large overlap volume 100 3 Lack of systematic differences between binding to the wt versus the mutated enzyme indicates that activity against mutants is connected with the structural features of the ligand rather than the energy of their    See Answer
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