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How is pain sensation modulated by other sensory input? Please briefly describe the mechanism and speculate on...

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Medical Sciences

Howis pain sensation modulated by other sensory input? Please brieflydescribe the mechanism and speculate on why such a modulatorypathway evolved.

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The modulation of pain by electrical brain stimulation results from the activation of descending inhibitory fibers which modulate block the input and output of laminae I II V and VII neurons The route from the PAG to the spinal cord is not direct It appears to involve a link with the 5HTrich raphe nuclei as well as norepinephrine NE from the locus    See Answer
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